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LETTER TO THE EDITOR
Year : 2012  |  Volume : 4  |  Issue : 3  |  Page : 195  

Urinary pH, melamine, and kidney stone formation


Wiwanitkit House, Bangkhae, Bangkok, Thailand

Date of Web Publication18-Oct-2012

Correspondence Address:
Somsri Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok, Thailand 10160
Thailand
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DOI: 10.4103/0974-7796.102678

PMID: 23248531

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How to cite this article:
Wiwanitkit S, Wiwanitkit V. Urinary pH, melamine, and kidney stone formation. Urol Ann 2012;4:195

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Urinary pH, melamine, and kidney stone formation. Urol Ann [serial online] 2012 [cited 2019 Oct 16];4:195. Available from: http://www.urologyannals.com/text.asp?2012/4/3/195/102678

Sir,

A recent publication on urinary pH, melamine, and kidney stone formation is very interesting. [1] Lu et al. reported "an association of gender and urinary pH with melamine-associated kidney stone formation risk". [1] This can be useful epidemiological information. However, some facts of medical biochemistry should be discussed. The reported pH in this publication is not clear. Only a value of < and ≥6.5 can be read. Indeed, the correlation can be directly assessed by the correlation study between the exact urine pH value and solubility. Based on chemical structure, melamine is a base and increases solubility in acidic conditions (very good if pH is lower than 4). [2] However, it is a fact that the range of human urine pH is not wide (4.5-8); hence, the solubility of melamine might be affected slightly.

 
   References Top

1.Lu X, Wang J, Cao X, Li M, Xiao C, Yasui T, et al. Gender and urinary pH affect melamine-associated kidney stone formation risk. Urol Ann 2011;3:71-4.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.WHO. Background Paper on the Chemistry of Melamine Alone and in Combination with Related Compounds. Available online at www.who.int/entity/foodsafety/fs_management/Melamine_2.pdf.  Back to cited text no. 2
    




 

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