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COMMENTARY
Year : 2013  |  Volume : 5  |  Issue : 2  |  Page : 102  

Urinary prostate specific antigen, usefulness is still a matter of controversy


Consultant Urologist, Department of Urology, Dossary Hospital, Alkhobar, Saudia Arabia, Fellow of VRIEJ University, Amsterdam-Netherland and Mansoura Urology and Nephrology Center, Mansoura University, Egypt

Date of Web Publication3-Apr-2013

Correspondence Address:
Ihab Ahmed Hekal
Consultant Urologist, Department of Urology, Dossary Hospital, Alkhobar, Saudia Arabia, Fellow of VRIEJ University, Amsterdam-Netherland and Mansoura Urology and Nephrology Center, Mansoura University, Egypt

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PMID: 23798867

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How to cite this article:
Hekal IA. Urinary prostate specific antigen, usefulness is still a matter of controversy. Urol Ann 2013;5:102

How to cite this URL:
Hekal IA. Urinary prostate specific antigen, usefulness is still a matter of controversy. Urol Ann [serial online] 2013 [cited 2020 Aug 8];5:102. Available from: http://www.urologyannals.com/text.asp?2013/5/2/102/110007

Although the value of urinary prostate specific antigen (PSA) has limited clinical applications, the authors in this original manuscript [1] has achieved that neither fresh nor dry urinary PSA (uPSA) reflect any serum PSA values, and therefore, the clinical reflection as a diagnostic tool in prostate cancer was poor.

However, few researches in English literature have identified usefulness of urinary PSA. The uPSA as a ratio with serum PSA has been proved as a promising tool to discriminate between benign and malignant prostate. [2],[3],[4] Pejcic et al. in his context [5] in 2005 stated that determination of uPSA cannot differentiate BPH and prostate cancer. However, within localized prostate cancer patients in his study, uPSA can provide additional information concerning T-staging. Later on, Pejcic with his colleagues in 2009 [6] found a correlation between lower uPSA and tumor volume. In another words, the uPSA is still an active topic that needs more studies.

In the presented manuscript, some points should be highlighted. PSA was within the normal range (in the current study [1] mean 1.1 ng/dl), this was denied any pathological background, so that no pathological support with a prostatic biopsy is a lacking point. Selection of 1, 7 and 28 days of dried uPSA may reflect a forensic interest.

In general, I agree with authors in the advantages of urinary collection of samples being better for providers and easier for the patients. Thereafter, continued work on uPSA is an interesting promising topic to find the relation with prostatic diseases.

 
   References Top

1.Hasan S. Saðlam, Osman Köse, Fatma Özdemir, Öztuð Adsan. Do the values of prostate specific antigen obtained from fresh and dried urine reflect the serum measurements. Urology 2013;5:99-101.  Back to cited text no. 1
    
2.Irani J, Salomon L, Soulié M, Zlotta A, de la Taille A, Doré B, et al. Urinary/serum prostate-specific antigen ratio: Comparison with free/total serum prostate-specific antigen ratio in improving prostate cancer detection. Urology 2005;65:533-7.  Back to cited text no. 2
    
3.Hillenbrand M, Bastian M, Steiner M, Zingler C, Müller M, Wolff JM, et al. Serum-to-urinary prostate-specific antigen ratio in patients with benign prostatic hyperplasia and prostate cancer. Anticancer Res 2000;20:4995-6.  Back to cited text no. 3
    
4.Bolduc S, Lacombe L, Naud A, Grégoire M, Fradet Y, Tremblay RR. Urinary PSA: A potential useful marker when serum PSA is between 2.5 ng/mL and 10 ng/mL. Can Urol Assoc J 2007;1:377-81.  Back to cited text no. 4
    
5.Pejcic T, Hadzi-Djokic J, Acimovic M, Topuzovic C, Milkovic B, Janjic A. Urinary prostate specific antigen: Is the clinical use likely? Acta Chir Iugosl 2005;52:69-74.  Back to cited text no. 5
    
6.Pejciæ T, Hadzi-Djokiæ J, Markoviæ B, Dragiæeviæ D, Glisiæ B, Laliæ N, et al . Urinary PSA level and relative tumor volume after prostate biopsy. Acta Chir Iugosl 2009;56:17-21.  Back to cited text no. 6
    




 

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