Urology Annals
About UA | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionLogin 
Urology Annals
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1725   Home Print this page  Email this page Small font size Default font size Increase font size


 
Table of Contents
CASE REPORT
Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 173-175  

Primary neuroendocrine tumor of the testis


1 Department of Pathology, Armed Forces Hospital - Southern Region, Khamis Mushayt, Saudi Arabia
2 Department of Pathology, College of Medicine, King Khalid University, Saudi Arabia
3 Department of Urology, Armed Forces Hospital - Southern Region, Khamis Mushayt, Saudi Arabia

Date of Submission16-Jun-2012
Date of Acceptance05-Sep-2012
Date of Web Publication15-Apr-2014

Correspondence Address:
Mubarak Al-Shraim
Department of Pathology, King Khalid University, College of Medicine, 61421 Abha, PO Box 641
Saudi Arabia
Login to access the Email id


DOI: 10.4103/0974-7796.130662

PMID: 24833836

Rights and Permissions
   Abstract 

Testicular neuroendocrine tumor is rare. It accounts for less than 1% of all testicular neoplasms. More than 60 cases have been published in the literature. A 27-year-old man presented with left testicular mass and underwent radical orchidectomy. Histological examination showed neuroendocrine tumor, confirmed by immunohistochemistry and electron microscopy. The patient showed no evidence of metastasis over 1-year follow-up post-orchidectomy in spite of extensive tumor necrosis.

Keywords: Neuroendocrine tumor, orchidectomy, testis


How to cite this article:
Alsharif S, Al-Shraim M, Alhadi A, Al-Aown A, Fooshang F, Eid R. Primary neuroendocrine tumor of the testis. Urol Ann 2014;6:173-5

How to cite this URL:
Alsharif S, Al-Shraim M, Alhadi A, Al-Aown A, Fooshang F, Eid R. Primary neuroendocrine tumor of the testis. Urol Ann [serial online] 2014 [cited 2020 Feb 17];6:173-5. Available from: http://www.urologyannals.com/text.asp?2014/6/2/173/130662


   Introduction Top


Neuroendocrine tumors are more frequently arisen from the embryonic gut. Testicular neuroendocrine tumor can occur as a primary or as metastases. Primary neuroendocrine tumors of the testis are rare. The cell of origin of testicular neuroendocrine tumor is unknown. Here, we report a case of primary testicular neuroendocrine tumor in a young man. The national data of such a tumor is extremely limited. The morphological findings and biological behavior of this rare tumor are discussed.


   Case Report Top


A 27-year-old man presented with a history of painless swelling of the left testis mass for 7 months. Physical examination revealed nontender firm testicular mass. Scrotal ultrasound revealed a well-defined oval heterogenous hyperechoic hypervascularized mass in the left testis measuring 3.7 × 2.7 cm, associated with mild hydrocele [Figure 1]. The right testis appeared normal. Chest X-ray and CT scan of the abdomen were normal. Laboratory investigations showed: Quantitative beta-HCG <3.0 (normal <5.0) U/L, AFP 3.0 (normal <15.0) micro g/L. The patient underwent surgery for exploration and possible radical orchidectomy. Intraoperative consultation was considered and wedge biopsy was sent for frozen section examination which showed a round cell tumor with neuroendocrine features associated with extensive necrosis. Therefore, radical orchidectomy was performed.
Figure 1: Testicular ultrasound showing heterogenous mass in the left testicle

Click here to view


Macroscopically, the tumor showed multiple yellow confluent nodules measuring up to 6.2 cm, associated with foci of necrosis. The epididymis and spermatic cord were unremarkable.

Microscopically, the tumor cells were arranged in nests and solid islands with rosettes formation. Extensive tumor necrosis was present [Figure 2]. Tumor cells were round with mild pleomorphism and had eosinophilic cytoplasmic granules [Figure 3]. The mitosis was rarely seen.
Figure 2: Photomicrograph original magnifi cation ×20; Hematoxylin and eosin stain) showing nests of neuroendocrine tumor with extensive necrosis (asterisk)

Click here to view
Figure 3: Photomicrograph (original magnifi cation ×40; Hematoxylin and eosin stain) showing tumor cells arranged in sheet of polygonal cells with moderate cytoplasm and fi ne stippled chromatin patten

Click here to view


There were no invasion to tunica albuginea and no intratubular germ cell neoplasia. The tumor mass was submitted entirely, and showed no teratomatous elements.

On immunohistochemistry, the tumor was positive for chromogranin, synaptophysin, and neuron-specific enolase (NSE). MIB-1 proliferative index was less than 1%. Ultrastructural examination of the tumor cells by transmission electron microscope (TEM) revealed the multiple intracytoplasmic neurosecretory granules [Figure 4].
Figure 4: Electron micrograph showing intracytoplasmic neurosecretory granules

Click here to view



   Discussion Top


Neuroendocrine tumor commonly arises from intestinal and respiratory epithelium. Neuroendocrine tumor of the testis is a rare tumor and accounts for less than 1% of all testicular neoplasms. [1] More than 60 cases have been reported to date. [2],[3] The first case reported in Saudi Arabia and Middle East was in 1997. [4]

The reported cases ranged from 10 to 83 years of age with higher incidence in the fifth and sixth decade of life. [2],[4] Most patients present with unilateral painless testicular mass. 16% of patients present with symptoms of neuroendocrine tumor syndrome. [3],[5] Eleven percent of primary testicular neuroendocrine tumors are associated with metastasis. [6]

The neuroendocrine tumors of the testis occur as a primary testicular neuroendocrine tumor; or metastatic neuroendocrine tumor to the testis. The primary testicular neuroendocrine tumor can be further divided into: 1) primary pure testicular neuroendocrine tumor; and 2) associated with teratoma or dermoid/epidermoid cysts. [2],[4],[7] Once a testicular neuroendocrine tumor has been found, a metastatic neuroendocrine tumor to the testis should be excluded. [3],[8] The presence of teratomatous elements sufficiently excludes the primary site outside the testicles. So, it is important to submit the tumor mass entirely and look for any additional lineage of differentiation. Twenty-five percent of primary testicular neuroendocrine tumors are associated with teratoma. [9]

Histogenesis of pure neuroendocrine tumor of the testis remains unclear. Two theories have been implicated regarding the mode of origin; derived from teratoma (germ cell origin) or arising in argentaffin cells located in crypts of Lieberkühn. [8],[10] The later also present in gastrointestinal tract and bronchial mucosa. However, in a study involved three pure testicular neuroendocrine tumors suggested that pure testicular neuroendocrine tumor might have different genetic background other than germ cell tumor. [11]

Histologically, neuroendocrine tumor is characterized by presence of nests of small round cells with uniform nuclei forming small acini and rosettes or sheets. The cells have eosinophilic granules in the cytoplasm and granular chromatin within the nuclei. The tumor cells stained positively for neuroendocrine markers like chromogranin and synaptophysin.

In our case the frozen section showed round tumor cells with neuroendocrine features associated with extensive necrosis. The presence of necrosis does not correlate with the malignant behavior of the tumor and doesn't predict the propensity for metastases. [5]

Radical orchidectomy is the treatment of choice; however, the need for adjuvant therapy depending on histological grading remains unclear. [2],[7] Octreotide analog can improve the neuroendocrine (carcinoid) syndrome and stabilize the tumor. [3]

The rarity of testicular neuroendocrine tumor is a limiting factor to understand the biological behavior of the tumor on which a modern classification and prediction of prognosis can be reached. However, the localized testicular neuroendocrine tumor has excellent prognosis after surgery. [2],[3],[7] Neuroendocrine tumor can develop metastasis 7 years after the initial treatment. [3] Few cases reported metastases 5 and 19 years later. [4] 50% of testicular neuroendocrine tumor with carcinoid syndrome metastasized and the larger tumor the higher risk for metastasis. [5] The association with teratoma has a prognostic value depending on the age; Postpubertal teratomatous neuroendocrine has advert prognosis. [2]

Because a metastatic potential exists, long-term follow-up is indicated. Regular physical examination, urinary 5-HIAA, abdominal CT scan, and gastrointestinal contrast can be exercised for follow-up evaluation. [2],[3],[4],[7],[12]


   Conclusions Top


Primary testicular neuroendocrine tumor is very rare. It is crucial to submit the entire gross specimen for histopathologic examination to rule out an existing of other germ cell elements. The patient showed no evidence of metastasis over 1-year follow-up post-orchiectomy in spite of presence of extensive tumor necrosis. Long-term follow-up is warranted for such a testicular neoplasm.

 
   References Top

1.Ulbright TM, Amin MB, Young RH. Tumors of the Testis, Adnexa, Spermatic Cord, And Scrotum. Washington, DC; Armed Forces Institute of Pathology; 1999; 61. Atlas of Tumor Pathology; Third series, Fascicle 25.  Back to cited text no. 1
    
2.Wang WP, Guo C, Berney DM, Ulbright TM, Hansel DE, Shen R, et al. Primary carcinoid tumors of the testis: Clinicopathological study of 29 cases. Am J Pathol 2010;34:519-24.  Back to cited text no. 2
    
3.Stroosma OB, Delaere KP. Carcinoid Tumours of the Testis. BJU Int 2008;101:1101-5.  Back to cited text no. 3
    
4.Kardar AH, Tulbah A, Peracha A, Merdad T, Al-Mathami A. Primary carcinoid tumor of testis. Ann Saudi Med 1997;17:223-5.  Back to cited text no. 4
    
5.Zavala-Pompa A, Ro JY, el-Naggar A, Ordóñez NG, Amin MB, Pierce PD, et al. Primary carcinoid tumor of testis. Immunohistochemical, Ultrastructural, and DNA flow cytometric study of three cases with a review of the literature. Cancer 1993;72:1726-32.  Back to cited text no. 5
    
6.Sutherland RS, Wettlaufer JN, Miller GJ. Primary carcinoid tumor of the testicle: A case report and management schema. J Urol 1992;148:880-2.  Back to cited text no. 6
    
7.Reyes A, Moran CA, Suster S, Michal M, Dominguez H. Neuroendocrine carcinoma (carcinoid Tumor) of the testis, clinicopathologic and immunohistochemical study of ten cases. Am J Pathol 2003;120:182-7.  Back to cited text no. 7
    
8.Talerman A, Gratama S, Miranda S, Okagaki T. Primary carcinoid tumor of the testis. Case report, ultrastructure and review of the literature. Cancer 1978;42:2696-706.  Back to cited text no. 8
[PUBMED]    
9.Thomas JC, Jones JS. Primary carcinoid tumor of the testis found at the time of elective sterilization. J Androl 2004;25338-9.  Back to cited text no. 9
    
10.Abbosh PH, Zhang S, Maclennan GT, Montironi R, Lopez-Beltran A, Rank JP, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res 2008;14:1393-6.  Back to cited text no. 10
    
11.Kato N, Motoyama T, Kameda N, Hiruta N, Emura I, Hasegawa G, et al. Primary carcinoid tumor of the testis: Immunohistochemical, Ultrastructural and FISH analysis with review of the literature. Pathol Int 2003;53:680-5.  Back to cited text no. 11
    
12.Hayashi T, Iida S, Taguchi J, Miyajima J, Matsuo M, Tomiyasu K, et al. Primary carcinoid of the testis associated with carcinoid syndrome. Int J Urol 2001;8:522-4.  Back to cited text no. 12
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
   Conclusions
    References
    Article Figures

 Article Access Statistics
    Viewed1690    
    Printed31    
    Emailed0    
    PDF Downloaded231    
    Comments [Add]    

Recommend this journal