Urology Annals
About UA | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionLogin 
Urology Annals
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1215   Home Print this page  Email this page Small font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 298-304

Cystatin C for early detection of acute kidney injury after laparoscopic partial nephrectomy


1 Department of Urology of Laval University; Laval University Cancer Research Centre, CHU de Québec - L’Hôtel-Dieu de Québec, Québec, Qc, Canada
2 Laval University Cancer Research Centre, CHU de Québec - L'Hôtel-Dieu de Québec, Québec, Qc, Canada
3 Department of Urology of Laval University, CHU de Québec - L'Hôtel-Dieu de Québec, Québec, Qc, Canada

Correspondence Address:
Yves Caumartin
Department of Urology of Laval University; Laval University Cancer Research Centre, CHU de Québec - L’Hôtel-Dieu de Québec, Québec, Qc
Canada
Login to access the Email id


DOI: 10.4103/0974-7796.140988

PMID: 25371605

Rights and Permissions

Introduction and Objectives : Mortality due to AKI has not changed significantly over the past 50 years. This is due in part to failure to detect early AKI and to initiate appropriate therapeutic measures. There is therefore a need to identify biomarkers that would improve the early detection of AKI. The objective of this study was to assess whether cystatin C levels obtained at specific timepoints during laparoscopic partial nephrectomy (PN) could be early predictors of AKI. Materials and Methods: Twenty-five patients underwent laparoscopic PN for organ-confined tumors. All procedures were performed by two surgeons in a single institution. Plasma samples were collected preoperatively, and post-unclamping at 5, 20, 120 min and on the day following surgery. Plasma cystatin C was measured by enzyme-linked immunosorbent assay. Correlation between levels of cystatin C and other parameters of interest were assessed in order to define cystatin C ability to predict AKI and loss of renal function following laparoscopic PN. Results: The mean baseline eGFR was 93 ml/min/1.73 m 2 . Warm ischemia time varied between 16 and 44 min. Post-operative day 1 (POD1) cystatin C levels compared to baseline were increased in 13 (52%) of the patients. There was a high correlation between the difference of POD 1 and baseline value, and eGFR in the immediate postoperative period (r = −0.681; P = 0.0002) and at 12-month follow-up (r = −0.460, P = 0.048). However, the variation in cystatin C levels at earlier timepoints were not associated to AKI nor renal function. Conclusions: High increase in POD 1 cystatin C levels from baseline may help identify patients with AKI and those at higher risk of chronic kidney disease, following laparoscopic PN.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1603    
    Printed50    
    Emailed0    
    PDF Downloaded306    
    Comments [Add]    

Recommend this journal