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CASE REPORT
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 366-368

Priapism associated with pregabalin


1 Department of Urology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
2 Department of Surgery, Division of Urology, King Khalid University Hospital, King Saud University, Saudi Arabia

Correspondence Address:
Danny M Rabah
Department of Surgery, Dvision of Urology, King Khalid University Hospital, KSU, PO Box 55068, Riaydh 11534
Saudi Arabia
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DOI: 10.4103/0974-7796.141012

PMID: 25371619

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Priapism is a well-known cause of erectile dysfunction. There are a wide variety of causes, including hemoglobinopathy, neurological diseases, and drugs. We present a case report of an Asian man who presented with priapism that was continuous for 3 days after taking three doses of pregabalin for chronic back pain. Cavernous aspiration, phenylephrine injection, and a winter shunt all failed to achieve detumescence. The patient then presented to our institution on the 5 th day of his initial presentation, and an El-Ghorab shunt was performed, after which detumescence and pain relief were achieved. We suggest that pregabalin might induce tumescence through acting on the α2δ1 subunit of voltage-gated calcium channels in the penile smooth muscle or by presynaptic inhibition of noradrenaline release. Further studies are warranted regarding the action of pregabalin and its effect on penile physiology.


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