Urology Annals
About UA | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionLogin 
Urology Annals
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1304   Home Print this page  Email this page Small font size Default font size Increase font size


 
Table of Contents
CASE REPORT
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 373-375  

Extensive xanthogranulomatous cystitis mimicking bladder cancer


Department of Urology, Institute of Nephro Urology, Bangalore, Karnataka, India

Date of Submission16-Sep-2013
Date of Acceptance06-Mar-2014
Date of Web Publication18-Sep-2014

Correspondence Address:
Amir M Ali
Department of Urology, Institute of Nephro Urology, Victoria Hospital Campus, Bangalore - 560 002, Karnataka
India
Login to access the Email id


DOI: 10.4103/0974-7796.141018

PMID: 25371622

Rights and Permissions
   Abstract 

Xanthogranulomatous cystitis (XC) is a rare benign disease of unknown etiology. A 39-year-old female presented with 2 month history of urgency, dysuria, lower abdominal mass. On physical examination a hard hypogastric mass was present fixed to the rectus muscle. Computerized tomography (CT) abdomen showed heterogeneous enhancing mass arising from the anterior bladder wall with infiltration of the overlying parietal wall. Cystoscopy revealed extensive growth involving the entire wall of the bladder. A biopsy showed cystitis with focal areas suggestive of urothelial neoplasia of unknown malignant potential. Suspecting bladder cancer, we proceeded with radical cystectomy with ileal conduit. Histopathology revealed cystitis cystica with XC of the entire bladder. This is, to our knowledge, the first time that a case has been found to be so extensive with infiltration of the parietal wall and second time that radical cystectomy has been performed for XC.

Keywords: Partial cystectomy, radical cystectomy, urachal remnant, xanthogranulomatous cystitis


How to cite this article:
Ali AM, Nelvigi GG, Keshavaiah VG, Ratkal CS. Extensive xanthogranulomatous cystitis mimicking bladder cancer. Urol Ann 2014;6:373-5

How to cite this URL:
Ali AM, Nelvigi GG, Keshavaiah VG, Ratkal CS. Extensive xanthogranulomatous cystitis mimicking bladder cancer. Urol Ann [serial online] 2014 [cited 2019 Oct 16];6:373-5. Available from: http://www.urologyannals.com/text.asp?2014/6/4/373/141018


   Introduction Top


Xanthogranulomatous change is characterized histologically by the presence of xanthoma cells (lipid-laden macrophages), multinucleated giant cells and cholesterol clefts. This change has been reported to occur in many sites, including the colon, ovary, pancreas, salivary gland, appendix, gall bladder, endometrium, brain and kidney. [1] However it is rarely reported in the bladder. We report one such case and discuss the treatments available.


   Case report Top


A 39-year-old female presented with two months history of urgency, dysuria, lower abdominal pain and lower abdominal swelling. There was no history of hematuria. On physical examination a hard hypogastric mass was present fixed to the rectus muscle. It was bimanually palpable. Routine blood investigations were normal. Urine routine was normal and culture was sterile. Ultrasonography showed a heterogeneous mass lesion from the anterior wall of the bladder. Contrast-enhanced computerized tomography (CECT) abdomen showed a heterogeneous enhancing mass 8.8 by 4.4 cm mass arising from the anterior bladder wall and dome, extending to the umbilicus with infiltration of the overlying parietal wall [Figure 1]. Cystoscopy revealed extensive growth involving the entire anterior wall and dome of the bladder extending to posterior wall. A biopsy done revealed cystitis with focal areas suggestive of urothelial neoplasia of unknown malignant potential. Metastatic workup was normal. As we could not rule out the presence of bladder tumor and due to the large size on the lesion, we proceeded with radical cystectomy with ileal conduit. The mass was found to be arising from the entire wall of the bladder and was infiltrating into the posterior rectus sheath and muscle, which needed to be partly resected along with the specimen [Figure 2]. Histopathology revealed cystitis cystica with xanthogranulomatous cystitis (XC) of the entire bladder wall [Figure 3] and [Figure 4]. There was no malignancy or urachal remnant. The post-operative course was uneventful and at 1 year follow up the patient is doing well.
Figure 1: Axial CECT section of the pelvis showing heterogeneously enhancing diffuse wall thickening of the bladder with infi ltration of the parietal wall. The arrow shows a well-defi ned enhancing cystic area in the anterior wall of the bladder

Click here to view
Figure 2: Gross findings revealed thickening of the entire bladder wall extending anteriorly into the posterior rectus sheath. A cystic cavity was seen in the anterior wall of the bladder

Click here to view
Figure 3: Hematoxylin and eosin section; x10, thin arrow - squamous metaplasia, medium-size arrow-sub-epithelial area with foamy histiocytes, thick arrow-transitional epithelium with inflammatory infi ltrate

Click here to view
Figure 4: Hematoxylin and Eosin; x40, the arrows show foamy histiocytes with abundant clear feathery cytoplasm with nuclei

Click here to view



   Discussion Top


XC is a rare benign inflammatory disease and majority of the reported cases are associated with urachal remnant or adenoma. [1] Twenty-seven cases have been reported in the literature, with the following clinical characteristics: Median age of 42 years (range, 16 to 76 years); no sexual predilection (13 cases have been of females); and the majority of lesions were located in the bladder dome (18 cases). Most cases are associated with aurachal remnant (17 cases). In the kidney xanthomatous change almost always develops in response to chronic low grade inflammation, often as a response to obstruction of urine. [1] The etiology of XC is unclear. Proposed explanations suggest a chronic inflammatory process caused by mechanisms such as (i) Immunological defect of the macrophage, [2] (ii) chronic infection of the urachal diverticulum or cyst, [3] (iii) gram negative or anaerobic bacteria such as in urinary tract infections, [4] or infection after tubal ligation, [5] (iv) foreign material such as retained suture material, [4] (v) local response to a bladder tumor, [2] and (vi) abnormal lipid metabolism and lipid accumulation in a macrophage. Histologically xanthogranulomatous lesions can be confused with malakoplakia and can be differentiated from it, by the absence of Michaelis-Guttmann bodies (basophilic lamellar inclusion bodies) and presence of large no of monocytes. [4] The symptoms of XC are nonspecific and difficult to distinguish from other disorders of the bladder, especially malignancy. XC most often presents with lower abdominal mass and symptoms of cystitis, such as frequency, urgency, and dysuria. [6] XC may be associated with carcinoma and can also mimic it. [2] Hence, it is important that the surgeon should be aware of the potential dual pathology and tumor should always be sought if this unusual condition is diagnosed in the bladder. Also, it is essential the pathologists should sample of the entire surgical specimen during gross examination. Although a trial of long-term broad-spectrum antibiotics has been suggested, medical treatment has not been found to be effective. As most of the patients had an associated urachal remnant, and as it is difficult to differentiate it from cancer, conservative treatment is rarely employed. The curative treatment of choice is surgery. [7] Localized disease or that involving the dome of the bladder may be amenable to simple excision of the lesion. However, when the disease is combined with urachal remnant or adenoma, partial cystectomy is preferred and is the most commonly performed procedure. Endoscopic excision has also been reported for small lesions. [8],[9] To our knowledge there has been only one report of radical cystectomy being performed. [10] Our case was not suited for partial cystectomy or endoscopic resection due to large size with extension to the parietal wall, and as we could not rule out malignancy, we proceeded with radical cystectomy.


   Conclusion Top


When a patient presents with a large bladder mass with significant symptoms and biopsy is not conclusive for malignancy, one should suspect chronic inflammatory pathology of the bladder. In such a situation radical cystectomy is a reasonable option due to high probability of bladder malignancy and lack of any beneficial effect with medical management even if it is a benign inflammatory pathology.

 
   References Top

1.Goel R, Kadam G, Devra A, Patel S, Modi P. Xanthogranulomatous cystitis. Int Urol Nephrol 2007;39:477-8.  Back to cited text no. 1
    
2.Bates AW, Fegan AW, Baithun SI. Xanthogranulomatous cystitis associated with malignant neoplasms of the bladder. Histopathology 1998;33:212-5.  Back to cited text no. 2
    
3.Chung MK, Seol MY, Cho WY, Seo HK, Kim JS. Xanthogranulomatouscystitis associated with suture material. J Urol 1998;159:981-2.  Back to cited text no. 3
    
4.Fornari A, Dambros M, Telöken C, Hartmann AA, Kolling J, Seben R. A case of xanthogranulomatous cystitis. IntUrogynecol J Pelvic Floor Dysfunct 2007;18:1233-5.  Back to cited text no. 4
    
5.Tai HL, Chen CC, Yeh KT. Xanthogranulomatous cystitis associated with anaerobic bacterial infection. J Urol 1999;162:795-6.  Back to cited text no. 5
    
6.Tan LB, Chiang CP, Huang CH, Chian CH.Xanthogranulomatous cystitis: A case report and review of the literature. Int Urol Nephrol 1994;26:413-7.  Back to cited text no. 6
    
7.Hayashi N, Wada T, Kiyota H, Ueda M, Oishi Y.Xanthogranulomatous cystitis. Int J Urol 2003;10:498-500.  Back to cited text no. 7
    
8.Yang KS, Kim YH, Seong YK, Kim IG, Han BH, Kim SJ.Xanthogranulomatous cystitis arising from the posterior wall of the bladder. Korean J Urol 2011;52:868-9.  Back to cited text no. 8
    
9.Singh SK, Khandelwal AK, Pawar DS, Sen R, Sharma S.Xanthogranulomatous cystitis: A rare clinical entity.Urol Ann 2010;2:125-6.  Back to cited text no. 9
[PUBMED]  Medknow Journal  
10.Ekici S, DoganEkici I, Ruacan S, Midi A. Xanthogranulomatous cystitis: A challenging imitator of bladder cancer. Scientific World Journal 2010;10:1169-73.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case report
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed1525    
    Printed43    
    Emailed0    
    PDF Downloaded179    
    Comments [Add]    

Recommend this journal