|LETTER TO EDITOR
|Year : 2015 | Volume
| Issue : 1 | Page : 128
Prostate-specific antigen obtained from fresh and dried urine
Beuy Joob1, Viroj Wiwanitkit2
1 Sanitation Medical Academic Center, Bangkok, Thailand
2 Adjunct Professor, Joseph Ayobabalola University, Nigeria
|Date of Web Publication||6-Jan-2015|
Sanitation Medical Academic Center, Bangkok
|How to cite this article:|
Joob B, Wiwanitkit V. Prostate-specific antigen obtained from fresh and dried urine. Urol Ann 2015;7:128
The recent publication on prostate-specific antigen (PSA) obtained from fresh and dried urine is very interesting.  Saglam et al. noted that "PSA values obtained from fresh and dried urine could not reflect serum PSA values. " In fact, the urine PSA level should not correlate to the serum PSA. There are many factors that can determine the secretion of PSA into urine including renal function. In addition, the method for determination of PSA level in urine should be carefully considered. In routine clinical chemistry laboratory, the application of the serum determination technique for measurement of analytes in urine is sometimes problematic and not acceptable. The important concern is on the detection limit and sensitivity of the analytical method. Focusing on diagnostic usefulness of urine PSA, it is proved that the urine PSA is useless in discrimination between benign and malignant prostate lesion.  Also, it is useless in following up of recurrence of prostate cancer.  Nevertheless, urine PSA is proposed for an advantage in monitoring "indicator of androgen suppression. "
| References|| |
Saglam HS, Köse O, Özdemir F, Adsan Ö. Do the values of prostate specific antigen obtained from fresh and dried urine reflect the serum measurements?. Urol Ann 2013;5:99-102.
Pejciæ T, Dimitrijeviæ V, Hadzi-Djokiæ J. Urinary PSA in monitoring of patients with prostate cancer. Acta Chir Iugosl 2012;59:57-60.