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Table of Contents
CASE REPORT
Year : 2015  |  Volume : 7  |  Issue : 3  |  Page : 408-409  

Synchronous bilateral ureteric metastasis from gastric cancer


1 Department of Urology, The Royal Hospital, Muscat, Oman
2 Department of Pathology, The Royal Hospital, Muscat, Oman
3 Department of Radiology, The Royal Hospital, Muscat, Oman

Date of Submission09-Feb-2015
Date of Acceptance04-Mar-2015
Date of Web Publication9-Jul-2015

Correspondence Address:
Qais Mohamed Al Hooti
The Royal Hospital, Muscat
Oman
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DOI: 10.4103/0974-7796.158501

PMID: 26229340

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   Abstract 

Distant metastasis to the ureters is uncommon. Moreover, isolated ureteric metastasis from gastric cancer is extremely rare and only sporadically reported. It indicates an advanced stage and carrier a very poor prognosis. We describe a case of synchronous bilateral ureteric metastasis from stomach adenocarcinoma after gastrectomy and chemoradiation. To our knowledge, it is the first case published in the literature with such presentation.

Keywords: Gastric cancer, ureteric metastasis, ureteral obstruction


How to cite this article:
George K, Al Hooti QM, Al Busaidy SS, Joseph M, Kamona A. Synchronous bilateral ureteric metastasis from gastric cancer. Urol Ann 2015;7:408-9

How to cite this URL:
George K, Al Hooti QM, Al Busaidy SS, Joseph M, Kamona A. Synchronous bilateral ureteric metastasis from gastric cancer. Urol Ann [serial online] 2015 [cited 2019 Apr 23];7:408-9. Available from: http://www.urologyannals.com/text.asp?2015/7/3/408/158501


   Introduction Top


Metastasis to the ureter from gastric cancer is rare. [1] Although few, such case reports are mostly from Japanese population while reports from other regions are scarce. [2] We report a patient with bilateral ureteric metastasis diagnosed during the follow-up after subtotal gastrectomy with concurrent chemo-radiotherapy for gastric cancer. Prognosis is poor and palliative treatment by relieving the obstruction together with chemotherapy is advocated.


   Case report Top


A 40-year-old male patient underwent a subtotal gastrectomy for T3N3M0 poorly differentiated gastric adenocarcinoma, followed by chemo-radiotherapy. He remained disease free and asymptomatic clinically with normal endoscopic and imaging studies. Two years later, upon follow-up he was incidentally found to have bilateral hydronephrosis and hydroureter. Magnetic resonance imaging (MRI) showed enhancing bilateral wall thickening of the lower third of the ureters without any periureteric soft tissue mass [Figure 1]. Retrograde urography and ureteroscopy revealed severe distal ureteric strictures [Figure 2]. The strictured area was biopsied, and a bilateral double J stents were inserted. Histopathology [Figure 3] showed adenocarcinoma infiltrating the smooth muscle resembling gastric adenocarcinoma. Positron emission tomography scan revealed increased activity at both ureteric areas, but there was no other distant positivity. Chemotherapy with Docitaxel and Folifox (5FU, leucovorin, oxaliplatin) was initiated, and the diseases have improved on follow-up.
Figure 1: An axial T2-weighted image showing irregular concentric wall thickening of both lower ureters with minimal periureteric fat stranding

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Figure 2: Stricture of the right lower ureter due to metastasis

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Figure 3: Metastatic mucin secreting adenocarcinoma in the ureter similar to gastric carcinoma

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   Discussion Top


Metastasis of gastric cancer to the ureter is very rare. It can be the first, sole and asymptomatic manifestation of stomach adenocarcinoma dissemination after a period of time. [2] However, the patient may present with loin pain due to hydronephrosis secondary to ureteral obstruction without any symptoms referable to the primary gastric lesion. [3],[4] Most of the published cases of gastric cancer metastasizing to ureter are from Japanese population. Shimoyama reported a similar case in which right nephroureterectomy was performed because of a suspected primary ureteric tumor, but subsequent histopathology confirmed the metastasis from a gastric malignancy. [3]

Presman and Ehrlich described a criterion for true ureteric metastasis, differentiating it from direct invasion by adjacent tissues. [5],[6] Our patient showed a ureteric wall enhancing lesion on MRI scans without periureteric mass indicating the disease was a true ureteric metastasis.

The prognosis of these cases is very poor and there is no report describes an effective surgical or medical therapy for this condition. [7] Chemotherapy including Docitaxel, 5FU and Oxaliplatin could be beneficial, depending on the performance status and the extent of the disease. [2]


   Conclusion Top


Although rare, ureteric metastasis can be the first and sole manifestation of gastric cancer dissemination. Ureteric metastasis represents an advanced stage of gastric cancer even if the stomach and other organs appear to be free of the disease. [3],[4] High index of suspicion of such a pathology; in addition to ureteroscopic biopsy will definitely avoid unnecessary nephroureterectomy. The prognosis is poor with very short survival and palliative treatment by drainage of the involved kidneys by an indwelling double J stent together with chemotherapy is advocated. [3]

 
   References Top

1.
Heesakkers JP, Delaere KP, Nap M. Metastasis of gastric carcinoma to the ureter. Urology 1999;54:561.  Back to cited text no. 1
    
2.
Bisof V, Juretic A, Pasini J, Coric M, Grgic M, Gamulin M, et al. Ureteral metastasis as the first and sole manifestation of gastric cancer dissemination. Radiol Oncol 2010;44:262-4.  Back to cited text no. 2
    
3.
Shimoyama Y, Ohashi M, Hashiguchi N, Ishihara M, Sakata M, Tamura A, et al. Gastric cancer recognized by metastasis to the ureter. Gastric Cancer 2000;3:102-5.  Back to cited text no. 3
    
4.
Yasdanbod A, Nojavan F, Malekzadh R. Ureteral metastasis as the first manifestation of asymptomatic gastric cancer. Arch Iran Med 2005;8:147-9.  Back to cited text no. 4
    
5.
Presman D, Ehrlich L. Metastatic tumors of the ureter. J Urol 1948;59:312-25.  Back to cited text no. 5
[PUBMED]    
6.
Cohen WM, Freed SZ, Hasson J. Metastatic cancer to the ureter: A review of the literature and case presentations. J Urol 1974;112:188-9.  Back to cited text no. 6
[PUBMED]    
7.
Oblak I, Anderluh F, Velenik V. Postoperative radiochemotherpy for gastric adenocarcinoma: Long term results. Radiol Oncol 2009;43:274-81.  Back to cited text no. 7
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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