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Table of Contents
REVIEW ARTICLE
Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 125-130  

Immediate ureterovaginal fistula following oocyte retrieval: A case and systematic review of the literature


1 Department of Urology, University of North Carolina, Chapel Hill, USA
2 Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill; UNC Fertility, Raleigh, North Carolina, USA
3 Department of Urology; Obstetrics and Gynecology, University of North Carolina, Chapel Hill; UNC Fertility, Raleigh, North Carolina, USA

Date of Submission24-Aug-2016
Date of Acceptance10-Jan-2017
Date of Web Publication10-Apr-2017

Correspondence Address:
Elysia Sophie Spencer
Department of Urology, University of North Carolina, 170, Manning Drive, 2115, Physicians Office Building, CB#7235, Chapel Hill, North Carolina
USA
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DOI: 10.4103/UA.UA_122_16

PMID: 28479761

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   Abstract 

The aim of this study is to report a case of acute ureterovaginal fistula (UVF) formation with immediate symptomatic presentation after transvaginal ultrasound-guided oocyte retrieval (TVOR) for in vitro fertilization (IVF) and to perform a systematic literature review of ureteral injuries during TVOR. A 33-year-old woman with a history of anovulatory infertility presented with severe abdominal pain and vaginal leakage immediately following TVOR for IVF. We systematically reviewed the current literature regarding ureteral injury resulting from TVOR and present a case of timely identification and management of a UVF followed by a successful pregnancy. Computed tomography cystogram with intravenous contrast and left retrograde pyelogram confirmed the diagnosis of UVF which was managed by placement of the left ureteral stent. The IVF cycle was converted to a freeze-all cycle. The ureteral stent was removed 4 weeks later, and a subsequent frozen embryo transfer cycle resulted in pregnancy. We present the 13th case of ureteral injury and the fourth case of UVF following TVOR. UVF formation is a rare complication after TVOR and may result in serious long-term morbidity if it is not identified and treated promptly. Clinicians must exercise a high degree of suspicion and prompt evaluation for potential ureteral injuries in women presenting with abdominal pain, urinary symptoms, or vaginal leakage following TVOR.

Keywords: Complication, in vitro fertilization, transvaginal oocyte retrieval, ureteral injury, urinary fistula


How to cite this article:
Spencer ES, Hoff HS, Steiner AZ, Coward RM. Immediate ureterovaginal fistula following oocyte retrieval: A case and systematic review of the literature. Urol Ann 2017;9:125-30

How to cite this URL:
Spencer ES, Hoff HS, Steiner AZ, Coward RM. Immediate ureterovaginal fistula following oocyte retrieval: A case and systematic review of the literature. Urol Ann [serial online] 2017 [cited 2017 Jul 28];9:125-30. Available from: http://www.urologyannals.com/text.asp?2017/9/2/125/204175


   Introduction Top


Transvaginal ultrasound-guided oocyte retrieval (TVOR) is standard of care for a couple undergoing in vitro fertilization (IVF), with >100,000 retrievals performed annually in the US.[1] Its minimally invasive nature, high efficacy, low complication rates, and the added advantage of not requiring general anesthesia have made it the preferred approach.[2],[3] Complication rates are low, with most studies citing a <5% complication rate.[4] The most common complications include severe abdominal pain (3%), vaginal bleeding (3%–8%), mild pelvic infections (~1%), and pelvic abscesses (0%–0.6%).[5],[6] Injury to pelvic viscera including the ureter and bladder are far less common, and ureteral injury has been reported in only 13 prior cases.[2],[3],[4],[5],[7],[8],[9],[10],[11],[12],[13],[14],[15] Such ureteral injuries have been associated with a wide range of complications, including three cases of delayed ureterovaginal fistula (UVF).[3],[9],[12]

We report the first case of UVF as an acute postoperative complication of TVOR in which the patient presented with severe flank pain and copious leakage of fluid per vagina immediately following the procedure.


   Case Report Top


A 33-year-old woman with a history of primary, anovulatory infertility underwent TVOR for planned IVF. The patient had a history of Class II obesity (body mass index [BMI] 35.6 kg/m 2) and sleep apnea. She had a history of a dilation and curettage and was also previously diagnosed with endometrial intraepithelial neoplasia (EIN) and was treated with megestrol acetate for 3 months. She had a negative endometrial biopsy before initiating treatment. After failing numerous ovulation induction cycles, the decision was made to proceed with IVF. She underwent a GnRH agonist down-regulation gonadotropin stimulation protocol and was triggered on stimulation day 10.

TVOR was performed under monitored anesthesia care during which both ovaries were easily visualized and multiple preovulatory follicles were observed. The patient's co-morbidities required minimized depth of anesthesia resulting in patient movement complicating the retrieval. Follicular aspiration was particularly challenging on the left side but ultimately resulted in recovery of 19 oocytes.

On emergence from anesthesia, the patient reported immediate and significant sharp, predominantly left-sided lower abdominal and back pain. After an hour, her pain was controlled and she was discharged. She presented to a local emergency room (ER) while en route home due to recurrent severe lower abdominal pain, emesis, and copious leakage of vaginal fluid.

In the ER, her vital signs were stable. She described flank pain and sharp left lower quadrant abdominal pain with exacerbations, followed by increased vaginal leakage and back pain. Her abdominal examination demonstrated a diffusely tender and moderately distended abdomen without rebound or peritoneal signs. She received intravenous (IV) analgesics and antiemetics, which moderately improved her pain and resolved her recurrent emesis. Her white blood cell count was elevated to 15.1 g/dL, and the remainder of her laboratories were normal. Of note, she also had a normal urinalysis without hematuria. A transvaginal ultrasound to rule out ovarian torsion demonstrated enlarged, heterogeneous ovaries with adequate blood flow bilaterally and was otherwise normal. She was admitted for pain control and further evaluation. The IVF cycle was converted to a freeze-all embryo cycle.

On admission, a computed tomography (CT) scan of the abdomen/pelvis with IV contrast was obtained on admission and demonstrated bilaterally enlarged ovaries with no evidence of ascites, hematoma, abscess, infection, or hydronephrosis. On hospital day 1, pelvic examination was performed to determine the etiology of the vaginal leakage. No fistula was visualized; however, fluid was noted to be pooling in the vagina. A sample of the fluid was sent for measurement of creatinine and returned 82.6 mg/dL confirming the presence of urine. An IV indigo carmine tampon test demonstrated blue dye in the vagina. An indwelling Foley catheter was placed but did not mitigate the amount of vaginal drainage.

Urology was consulted on hospital day 2 and recommended CT urogram of the abdomen/pelvis with IV contrast to include a delayed phase to evaluate the urinary tract, which demonstrated a small fistula extending from the distal left ureter to the vagina consistent with a UVF [Figure 1]. Cystoscopy demonstrated intact bladder urothelium and cystogram confirmed no evidence of bladder injury. Right retrograde pyelogram was normal; however, the left side revealed a small amount of contrast extravasation from the distal ureter without associated hydroureteronephrosis [Figure 2]. She subsequently underwent successful placement of a left double-J ureteral stent. Her Foley catheter was uneventfully removed 2 weeks later, and the left ureteral stent was removed 4 weeks later in the operating room after a the left retrograde pyelogram demonstrated resolution of the UVF.
Figure 1: Computed tomography cystogram with intravenous contrast demonstrates the (a) left ureter proximal to fistula; (b) a slight narrowing of the distal left ureter; (c) a small fistula extending from the distal left ureter to the vagina; (d) extravasation of contrast

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Figure 2: Intra-operative fluoroscopy demonstrates left retrograde pyelogram with a small amount of extravasation of contrast from the left distal ureter

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Eight weeks later, the patient elected to undergo a frozen embryo transfer of a single 5-day blastocyst. At the time of publication, the patient had an ongoing clinical pregnancy at <28 weeks of gestation.


   Materials and Methods Top


The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were utilized in the design and execution of this study. We performed a systematic literature review of the National Library of Medicine PubMed database on March 1, 2016 for all articles published before this date related to ureteral injuries during TVOR. The database was searched using the following keywords: Transvaginal oocyte retrieval, oocyte retrieval, oocyte recovery, ureteral injury, ureteral trauma, ureteral obstruction, UVF, and ureteral hemorrhage. The search was limited to English language articles. The reference lists of all primary and review articles were thoroughly searched to ensure a comprehensive inclusion of all relevant articles. After a preliminary screen was performed of all titles and abstracts, the full texts of the potentially eligible studies were obtained. These articles were then reviewed and studies were selected that included cases of any type of iatrogenic ureteral injury, which resulted from TVOR for IVF. Thirteen articles were identified including twelve case reports of ureteral injury during TVOR and one prospective review of complications following TVOR that included a single case of ureteral injury. The thirteen articles were included in the systematic review on ureteral injury following TVOR [Figure 3]. Data were extracted from all studies independently by the primary authors.
Figure 3: Flow diagram representing study selection

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   Discussion Top


TVOR is a safe, simple, and efficacious procedure.[16] Ureteral injury is exceedingly rare but can lead to significant urologic morbidity. We report the fourth case of UVF formation following TVOR and the first case in which a patient presented with acute symptoms immediately following the procedure.

To review, the ureter passes anterolaterally over the anterior fornix of the vagina and therefore lies in the direct path of the aspiration needle during TVOR. Given its anatomic position, ureteral injury is surprisingly rare.[3] Anatomic distortion can be caused by both the pressure of the transvaginal ultrasound probe and conditions commonly associated with female infertility such as endometriosis, pelvic inflammatory disease, and prior gynecologic surgery. Such distortion may increase the risk of ureteral injury.[8]

There are 13 previous reports in the literature of ureteral injury at the time of oocyte retrieval with a wide range of clinical presentations [Table 1].[2],[3],[4],[5],[7],[8],[9],[10],[11],[12],[13],[14],[15] Patients were between the ages of 26–37 and presented between 2 h to a few months with pelvic pain, fever, dysuria, nausea, emesis, continuous leakage per vagina, and gross hematuria.[10],[14] Four out of 13 patients had ureteral obstruction, two of which were managed with ureteral stent placement, one required ureteral re-implantation, and one patient ultimately required nephrectomy secondary to renal failure.[11],[13],[14],[15] Two out of 13 patients presented with gross hematuria and clot retention, one immediately postoperatively and one patient 4 days later, both of whom were ultimately managed with ureteral stent placement.[2],[4] One patient was diagnosed with uroretroperitoneum and a second with a ureteral perforation; both injuries were managed with ureteral stenting.[8],[10] Two patients presented with unspecified ureteral lesions, one patient had clear vaginal leakage and was treated with ureteral stenting,[7] whereas the other patient's management was not reported.[5] Finally, three patients presented with UVF.[3],[9],[12] We present the fourth reported case of UVF following TVOR.
Table 1: Summary of literature published on ureteral injury as a result of transvaginal oocyte retrieval

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Coroleu et al. reported the initial case of UVF after TVOR in 1997.[12] This case involved a 33-year-old female with a history of primary infertility for 7 years with a severe male factor etiology. She developed symptoms 5 days after the procedure including severe abdominal pain, dysuria and bladder spasms. She presented 7 days postoperatively and underwent renal ultrasound and cystoscopy, which demonstrated a mass posterior to the right hemitrigone causing external compression of the bladder. She underwent transvaginal drainage of a serosanguinous fluid collection within the vaginal wall. Only following incision and drainage of the fluid collection did she develop passing of urine per vagina, unlike the other cases in which leakage was spontaneous. She was later diagnosed with an UVF and was ultimately managed with an open ureteral reimplantation.

von Eye Corleta et al. subsequently reported a case in 2008 involving a 31-year-old female again with a 7 year history of primary infertility due to male factor, who presented 12 h after surgery with clear, odorless, vaginal drainage, and recurrent episodes of abdominal pain. She underwent ureteral stent placement.[3]

Finally, in 2009, Mongiu et al. reported a case of a 33-year-old female with history of unexplained infertility who presented after TVOR with a fever, leukocytosis and abdominal pain without urinary symptoms. She was empirically treated with antibiotics for presumed oophritis, her symptoms resolved, and she underwent embryo transfer 5 days later. Seven days after TVOR, she began developing increasing leakage of fluid per vagina. She was diagnosed with a delayed UVF after she presented with continuous vaginal leakage 21 days after oocyte retrieval. She was ultimately managed with nephrostomy tube placement after unsuccessful ureteral stent placement.[9]

Our patient is similar to those previously reported cases of UVF formation following TVOR in that her presenting symptoms included flank pain, lower abdominal pain and vaginal leakage. However, the delayed interval between presentation and diagnosis is much shorter in this case. This patient's presentation was unique given the acute onset of symptoms, including vaginal leakage immediately postoperatively and presentation for evaluation within 2 h of the oocyte retrieval. In all three prior cases of UVF formation, time to re-presentation was at least 12 h, and there had been a delayed onset of vaginal drainage of urine.[3] Of note, our patient had no signs of peritoneal irritation on presentation – likely due to early drainage of urine per vagina resulting in absence of true ureteral obstruction or urinoma formation.

Risk for ureteral injury may be increased with distortion of pelvic anatomy due to prior surgery or endometriosis. The case report presented by von Eye Corleta et al. was of a patient with a history of diagnostic laparoscopy, which could theoretically alter pelvic or abdominal anatomy by formation of adhesions.[3] The case of ureteral injury resulting in UVF reported by Mongiu et al. had undergone two prior TVORs, which could potentially have resulted in alterations in her pelvic anatomy due to adhesions as well.[9] While our patient had a history of EIN and dilation and curettage, it is unlikely that this would contribute to adhesions within the pelvis. The patient's retrieval was, however, complicated by her sleep apnea and elevated BMI.

This is the third case of a pregnancy following successful treatment of an UVF after TVOR.[9],[12] In addition, this is the second case of UVF that was successfully managed conservatively with ureteral stenting, demonstrating that this treatment option should be considered before more invasive interventions such as nephrostomy tube placement or open surgical repair.[3]


   Conclusions Top


TVOR remains a safe procedure; however, it is important to recognize the potential for significant, albeit rare, complications. The relatively rare nature of genitourinary complications following TVOR makes case reporting and systematic literature review necessary to empower urologists and reproductive specialists to identify ureteral injury early to allow for prompt intervention and prevention of long-term morbidity.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Van Voorhis BJ. Clinical practice. In vitro fertilization. N Engl J Med 2007;356:379-86.   Back to cited text no. 1
    
2.
Burnik Papler T, Vrtacnik Bokal E, Šalamun V, Galic D, Smrkolj T, Jancar N. Ureteral injury with delayed massive hematuria after transvaginal ultrasound-guided oocyte retrieval. Case Rep Obstet Gynecol 2015;2015:760805.   Back to cited text no. 2
    
3.
von Eye Corleta H, Moretto M, D'Avila AM, Berger M. Immediate ureterovaginal fistula secondary to oocyte retrieval – A case report. Fertil Steril 2008;90:2006.e1-3.   Back to cited text no. 3
    
4.
Catanzarite T, Bernardi LA, Confi no E, Kenton K. Ureteral trauma during transvaginal ultrasound-guided oocyte retrieval: A case report. Female Pelvic Med Reconstr Surg 2015;21:e44-5.   Back to cited text no. 4
    
5.
Ludwig AK, Glawatz M, Griesinger G, Diedrich K, Ludwig M. Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: Prospective study of >1000 oocyte retrievals. Hum Reprod 2006;21:3235-40.  Back to cited text no. 5
    
6.
Bennett SJ, Waterstone JJ, Cheng WC, Parsons J. Complications of transvaginal ultrasound-directed follicle aspiration: A review of 2670 consecutive procedures. J Assist Reprod Genet 1993;10:72-7.  Back to cited text no. 6
    
7.
Vilos AG, Feyles V, Vilos GA, Oraif A, Abdul-Jabbar H, Power N. Ureteric injury during transvaginal ultrasound guided oocyte retrieval. J Obstet Gynaecol Can 2015;37:52-5.  Back to cited text no. 7
    
8.
Grynberg M, Berwanger AL, Toledano M, Frydman R, Deffieux X, Fanchin R. Ureteral injury after transvaginal ultrasound-guided oocyte retrieval: A complication of in vitro fertilization-embryo transfer that may lurk undetected in women presenting with severe ovarian hyperstimulation syndrome. Fertil Steril 2011;96:869-71.  Back to cited text no. 8
    
9.
Mongiu AK, Helfand BT, Kielb SJ. Ureterovaginal fi stula formation after oocyte retrieval. Urology 2009;73:444.e1-3.  Back to cited text no. 9
    
10.
Fiori O, Cornet D, Darai E, Antoine JM, Bazot M. Uro-retroperitoneum after ultrasound-guided transvaginal follicle puncture in an oocyte donor: A case report. Hum Reprod 2006;21:2969-71.  Back to cited text no. 10
    
11.
Miller PB, Price T, Nichols JE Jr., Hill L. Acute ureteral obstruction following transvaginal oocyte retrieval for IVF. Hum Reprod 2002;17:137-8.  Back to cited text no. 11
    
12.
Coroleu B, Lopez Mourelle F, Hereter L, Veiga A, Calderón G, Martinez F, et al. Ureteral lesion secondary to vaginal ultrasound follicular puncture for oocyte recovery in in-vitro fertilization. Hum Reprod 1997;12:948-50.  Back to cited text no. 12
    
13.
Cahill DJ, Fox R, Wardle PG. Ureteral obstruction – A complication of oocyte retrieval. Fertil Steril 1994;61:787-8.  Back to cited text no. 13
    
14.
Jones WR, Haines CJ, Matthews CD, Kirby CA. Traumatic ureteric obstruction secondary to oocyte recovery for in vitro fertilization: A case report. J In Vitro Fert Embryo Transf 1989;6:185-7.  Back to cited text no. 14
    
15.
Fugita OE, Kavoussi L. Laparoscopic ureteral reimplantation for ureteral lesion secondary to transvaginal ultrasonography for oocyte retrieval. Urology 2001;58:281.  Back to cited text no. 15
    
16.
El-Shawarby S, Margara R, Trew G, Lavery S. A review of complications following transvaginal oocyte retrieval for in-vitro fertilization. Hum Fertil (Camb) 2004;7:127-33.  Back to cited text no. 16
    


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