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  Indian J Med Microbiol
 

Figure 2: Pregabalin targets the voltage-gated calcium channels, leading to inhibition of Ca++ influx into excitable cells. (1) Pregabalin acts on voltage-dependent Ca++ channels of the corporal smooth muscle, leading to decrease in Ca++ influx into the smooth muscle and a resultant decrease in free cytosolic Ca++ level and, ultimately, smooth muscle relaxation. (2) Pregabalin acts on the voltage-dependent Ca++ channels of the adrenergic nerves, which leads to decrease in the excitability of nerves and decrease in norepinephrine release, resulting in a decrease in the release of intracellular Ca++ stores

Figure 2: Pregabalin targets the voltage-gated calcium channels, leading to inhibition of Ca++ influx into excitable cells. (1) Pregabalin acts on voltage-dependent Ca++ channels of the corporal smooth muscle, leading to decrease in Ca++ influx into the smooth muscle and a resultant decrease in free cytosolic Ca++ level and, ultimately, smooth muscle relaxation. (2) Pregabalin acts on the voltage-dependent Ca++ channels of the adrenergic nerves, which leads to decrease in the excitability of nerves and decrease in norepinephrine release, resulting in a decrease in the release of intracellular Ca++ stores