Urology Annals
About UA | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionLogin 
Urology Annals
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 797   Home Print this page  Email this page Small font size Default font size Increase font size
Year : 2011  |  Volume : 3  |  Issue : 1  |  Page : 8-13

Prognostic significance of P27 (Kip 1) and MUC1 in papillary transitional cell carcinoma of the urinary bladder

1 Department of Histopathology, Benha Faculty of Medicine, Benha University, Egypt
2 Department of Urology, Benha Faculty of Medicine, Benha University, Egypt
3 Department of Surgery, Division of Urology, Mubarak Al-Kabir Hospital, Ministry of Health, Kuwait

Correspondence Address:
Hamdy Abdul-Halim
Department of Surgery (Division of Urology), Mubarak AI-Kabeer Hospital, PO Box 43787, Hawally 32052
Login to access the Email id

DOI: 10.4103/0974-7796.75857

PMID: 21346826

Rights and Permissions

Aim: To examine p27 (Kip 1) and MUC1 expression in specimens of papillary transitional cell carcinoma (PTCC) of the urinary bladder and to correlate their expression with the tumor grades,stages and outcome. Patients and Methods: Paraffin sections from previously diagnosed PTCC bladder were graded, staged and the patients were followed up for 5 years. Ten non-neoplastic urological lesions diagnosed as polypoid cystitis were taken as control. Three sections of 4 um thickness were obtained from every case. One was hematoxylin and eosin (H and E) stained for diagnosis, reviewing and confirmation. The other two sections were immunohistochemically stained for both p27and MUC1. The data of immunohistochemical results were correlated with the following conventional prognostic variables: tumor grade, stage, distant metastasis and 5 year survival. Results: The results showed a highly significant and an insignificant relationship between p27 expression and tumor grade and stage (P<0.01 and P>0.05), respectively. Correlating p27 expression with distant metastasis and overall survival showed a significant relationship with distant metastasis (P<0.05) and a highly significant one with overall survival (P<0.01). The results showed also a significant relationship between MUC1 expression and both tumor grade (P<0.01) and overall survival (P<0.05). Conclusion: p27 and MUC1 immunohistochemistry augment the classic histochemistry for the prognosis of PTCC of the bladder as well as improving the prediction of the patient outcome and survival.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded699    
    Comments [Add]    
    Cited by others 4    

Recommend this journal