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CASE REPORT
Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 103-107

Primitive neuroectodermal tumor/Ewing's sarcoma in adult uro-oncology: A case series from a developing country


1 Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi, Pakistan
2 Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi, Pakistan
3 Department of Uro-Oncology, Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi, Pakistan

Correspondence Address:
Rehan Mohsin
Department of Urology, Sindh Institute of Urology and Transplantation, Karachi - 74200
Pakistan
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DOI: 10.4103/0974-7796.82180

PMID: 21747604

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Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (PNET/EWS) is primarily a tumor of soft tissues and bones. Primary localization of PNET/EWS in genitourinary organs is rare. No data on this localization of PNET/EWS are available in literature from Pakistan. We searched our adult uro-oncology records from 1994 till date and identified all cases of adult genitourinary and adrenal PNET/EWS diagnosed on histology and immunohistochemistry. Their case records were reviewed to obtain data on demographics, presentation, pathologic features, management and outcome. Six cases were found; all were young and had aggressive disease at presentation. Four had renal PNET/EWS. One case each of prostate and adrenal PNET/EWS was seen. Surgery and chemotherapy formed the mainstay of management. Three patients (50%) died during treatment, two were lost to follow-up and one case with renal PNET/EWS showed good initial response to chemotherapy but was later on lost to follow-up. In conclusion, PNET/EWS should be considered in the differential diagnosis of genitourinary malignant tumors in young patients. These tumors are aggressive with poor outcome.


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