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ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 71-74

Gender and urinary pH affect melamine-associated kidney stone formation risk


1 School of Life Sciences, Liaoning University, Shenyang, China
2 Department of Clinical Laboratory Sciences, The Fourth People's Hospital, Shenyang, China
3 Department of Clinical Laboratory Sciences, The Eighth People's Hospital, Shenyang, China
4 School of Basic Medical Sciences, Shenyang Medical College, Shenyang, China
5 Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

Correspondence Address:
Bing Gao
School of Basic Medical Sciences, Shenyang Medical College, 146 Huanghe North Street, Shenyang 110034
China
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DOI: 10.4103/0974-7796.82171

PMID: 21747595

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Objectives : Melamine was known as a new risk for kidney stone due to recent incidences of milk powder contamination in China. Here, we performed a retrospective study to investigate whether age, gender, and urinary pH affect melamine-associated kidney stone risk. Materials and Methods : A retrospective review was performed of 217 children aged less than 3 years old. All children had a history of being fed with Sanlu milk powder contaminated by melamine, and underwent a clinical screening on kidney stone in Shenyang from November 2008 to February 2009. A comparison with the Chi-square was conducted between 83 cases and 125 normal subjects. The difference between children's gender, age, and urinary pH was evaluated. Results : A total of 208 subjects, 136 boys and 72 girls, were included in the study. Significant association was observed between melamine-associated kidney stone risk and gender [odds ratio (OR), 2.03; 95% confidence interval (CI), 1.11-3.74; P=0.02] and urinary pH (OR, 1.78; 95% CI, 1.01-3.11; P=0.04), respectively. Male children were at about twofold increased melamine-associated kidney stone risk compared with female children. Acidic urine showed about 1.78-fold increased melamine-associated kidney stone risk compared with normal urine. Conclusions : Our investigation results showed an association of gender and urinary pH with melamine-associated kidney stone formation risk.


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