Urology Annals
About UA | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionLogin 
Urology Annals
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 307   Home Print this page  Email this page Small font size Default font size Increase font size
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 366-368

Priapism associated with pregabalin

1 Department of Urology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
2 Department of Surgery, Division of Urology, King Khalid University Hospital, King Saud University, Saudi Arabia

Correspondence Address:
Danny M Rabah
Department of Surgery, Dvision of Urology, King Khalid University Hospital, KSU, PO Box 55068, Riaydh 11534
Saudi Arabia
Login to access the Email id

DOI: 10.4103/0974-7796.141012

PMID: 25371619

Rights and Permissions

Priapism is a well-known cause of erectile dysfunction. There are a wide variety of causes, including hemoglobinopathy, neurological diseases, and drugs. We present a case report of an Asian man who presented with priapism that was continuous for 3 days after taking three doses of pregabalin for chronic back pain. Cavernous aspiration, phenylephrine injection, and a winter shunt all failed to achieve detumescence. The patient then presented to our institution on the 5 th day of his initial presentation, and an El-Ghorab shunt was performed, after which detumescence and pain relief were achieved. We suggest that pregabalin might induce tumescence through acting on the α2δ1 subunit of voltage-gated calcium channels in the penile smooth muscle or by presynaptic inhibition of noradrenaline release. Further studies are warranted regarding the action of pregabalin and its effect on penile physiology.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded349    
    Comments [Add]    
    Cited by others 1    

Recommend this journal