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CASE REPORT
Year : 2015  |  Volume : 7  |  Issue : 2  |  Page : 262-264

Upgrading prostate cancer following proton beam therapy


1 Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
2 Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
3 Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Center for Interventional Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Correspondence Address:
Dr. Peter A Pinto
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1210, Building 10, CRC Room 2W-5940, Bethesda, MD 20892-1210
USA
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DOI: 10.4103/0974-7796.152944

PMID: 25837674

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Pre- and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heterogenous among different patients and even within a single tumor. When assessing residual tumor it is important to understand biopsy evaluation in the post-RT setting. We present the case of a poorly differentiated prostate adenocarcinoma following proton beam RT in a 45-year-old man with pre-RT Gleason 4 + 3 = 7 disease diagnosed in the setting of an elevated serum prostate-specific antigen level.


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