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Year : 2015  |  Volume : 7  |  Issue : 3  |  Page : 383-386

Chromophobe renal cell carcinoma of the kidney with neuroendocrine differentiation: A case report with review of literature

Department of Pathology, King Abdulaziz University, Jeddah, Saudi Arabia

Correspondence Address:
Ghadeer A Mokhtar
Department of Pathology, Pathology Laboratory, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah 21589
Saudi Arabia
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DOI: 10.4103/0974-7796.158506

PMID: 26229333

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Chromophobe renal cell carcinoma (chRCC) is a distinctive type of malignant kidney tumor characterized by large cells with defined cell membrane. Primary renal neuroendocrine tumors (NET) are rare with morphology similar to NET at other sites. There are few case reports describing the coexistence of these 2 neoplasms within the same tumor mass. We describe a case of chRCC with neuroendocrine features in a 70-year-old male patient who presented with hematuria and right flank pain. The histological and immunohistochemical features of both components were characteristic with no overlapping features. The neuroendocrine element was associated with nodal metastasis.

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