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Year : 2016  |  Volume : 8  |  Issue : 3  |  Page : 387-390

Breast metastases from a malignant peripheral nerve sheath tumor of the kidney: An unusual presentation

1 Department of Infectious Diseases, Beaumont Hospital, Royal Oak, MI, USA
2 Department of Pathology, Crittenton Hospital Medical Center, Rochester, MI, USA
3 Department of Urology, Crittenton Hospital Medical Center, Rochester, MI, USA

Correspondence Address:
Atul Rajpurkar
Crittenton Hospital Medical Center, 2450 Walton Blvd, Rochester, MI 48309
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DOI: 10.4103/0974-7796.184878

PMID: 27453670

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Malignant peripheral nerve sheath tumors (MPNSTs) are extremely rare soft tissue sarcomas of ectomesenchymal origin. They are commonly seen in association with neurofibromatosis type 1 (NF-1), but can also occur without a history of NF (isolated MPNST). MPNSTs are most commonly located on the extremities (brachial and sacral plexus), head and neck, and trunk regions and are rarely reported in genitourinary organs. These tumors are aggressive, with a high recurrence rate and distant metastases. MPNST involving the kidney is extremely rare, and review of the literature using PubMed from 2001 to 2014 revealed eight cases of MPNST involving the kidney (seven, primarily involving the kidney and one metastatic MPNST of the kidney). Herein, we describe a case of breast metastases from an MPNST of the kidney without a history of NF-1. The patient was initially diagnosed with a spindle cell neoplasm of the kidney with peripheral nerve sheath differentiation. Eventually, the patient developed a right breast mass that was diagnosed as metastatic MPNST. The patient refused any kind of treatment and died 6 months later in hospice care.

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