| CASE REPORT |
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| Year : 2020 | Volume
: 12
| Issue : 2 | Page : 180-183 |
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A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
Laura Stokkel1, Henk G van der Poel1, Sigrun I Langbein2, J Martijn Kerst3, Jeroen de Jong4, Bas W. G van Rhijn1
1 Department of Urology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
2 Department of Urology, Zaans Medical Center, Zaandam, The Netherlands
3 Department of Medical Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
4 Department of Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Correspondence Address:
Dr. Bas W. G van Rhijn
Department of Urology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 Cx Amsterdam
The Netherlands
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DOI: 10.4103/UA.UA_38_19 
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We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was diagnosed with prostate cancer. He received a radical prostatectomy with pelvic lymph node dissection. Due to recurrent prostate cancer, he underwent salvage radiation to the prostatic fossa and pelvic lymph node stations with hormonal treatment for 3 years. After approximately 1.5 years of chemical castration, a significant increase in testosterone level occurred. Further, diagnostic evaluations and surgery revealed a testosterone-producing LCT metastasis in the retroperitoneum.
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