Urology Annals

COMMENTARY
Year
: 2014  |  Volume : 6  |  Issue : 4  |  Page : 368--369

Pregabalin and priapism


Ranjith Ramasamy 
 Department of Urology, Baylor College of Medicine, Houston, TX, USA

Correspondence Address:
Ranjith Ramasamy
One Baylor Plaza, N 730, Baylor College of Medicine, Houston, TX 77030
USA




How to cite this article:
Ramasamy R. Pregabalin and priapism.Urol Ann 2014;6:368-369


How to cite this URL:
Ramasamy R. Pregabalin and priapism. Urol Ann [serial online] 2014 [cited 2021 Jun 22 ];6:368-369
Available from: https://www.urologyannals.com/text.asp?2014/6/4/368/141014


Full Text

Priapism is a persistent, unwanted erec tion that is not associated with sexual desire or sexual stimulation. There are three types of priapism; ischemic priapism, non-ischemic priapism and recurrent (stuttering) priapism. Ischemic priapism can cause injury to cavernous tissue; and therefore needs emergent

evaluation and treatment. Aspiration and irrigation of corpus cavernosum is successful if erection lasts <24 h.[1] In the case reported, the patient had an erection lasting ~5 days. A distal cavernoglanular shunt, which the authors performed, should be the first choice in such cases.

Pregabalin is an anticonvulsant used in treatment of neuropathic pain, fibromyalgia and certain subtypes of seizures. The authors report the first case of priapism associated with pregabalin. In an animal study, pregabalin decreased the expression of neuronal nitric oxide synthase (nNOS and endothelial NOS).[2] Decrease in nitric oxide synthesis leads to tumescence and not erection. Hence, it is plausible that priapism could have been idiopathic.

References

1Kovac JR, Mak SK, Garcia MM, Lue TF. A pathophysiology-based approach to the management of early priapism. Asian J Androl 2013;15:20-6.
2Amany S, Heba K. Effect of pregabalin on erectile function and penile NOS expression in rats with streptozotocin-induced diabetes. Exp Clin EndocrinolDiabetes 2013;121:230-3.