Urology Annals

: 2014  |  Volume : 6  |  Issue : 4  |  Page : 390--391

Inflammatory pseudotumor of urinary bladder: Beware lest we forget

Pankaj Kumar Garg 
 Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Pankaj Kumar Garg
Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi - 110 095

How to cite this article:
Garg PK. Inflammatory pseudotumor of urinary bladder: Beware lest we forget.Urol Ann 2014;6:390-391

How to cite this URL:
Garg PK. Inflammatory pseudotumor of urinary bladder: Beware lest we forget. Urol Ann [serial online] 2014 [cited 2021 Oct 25 ];6:390-391
Available from: https://www.urologyannals.com/text.asp?2014/6/4/390/141013

Full Text

The inflammatory pseudotumor (IPT) has always been baffling clinicians with its clinic-radiological presentations; IPT masquerades malignancy so closely that it results in radical resection more often than not. IPT was first described by Brunn in 1939; [1] however the name "IPT" was coined by Umiker and Iverson [2] in 1954. As it has an inflammatory background and appears as a mass like lesion that is non-neoplastic, [3] the word "IPT" seems justified. Since the first description of two cases of IPT involving the lung by Brunn, it has been reported to involve almost every organ of the body. [4] Its pathogenesis is still obscure; a number of inflammatory and immunological factors have been implicated. Trauma, minor surgery, associated malignancy and infections, all have been postulated to be the inciting factors. [4] The characteristic pathological features of IPT include presence of acute and chronic inflammatory cells and myofibroblastic inflammatory cells. The vimentin positive myofibroblastic cells of IPT can be differentiated from those of malignant process by virtue of having minimal atypia and nuclear polymorphism and low mitotic activity. Immuno-histochemical studies of T and B cell populations helps in distinguishing IPT from lymphoma. Both T and B cells are present in IPT, while either clonal population of T or B cells predominates in Lymphoma. Moreover, the heterogenic nature of inflammatory cell population in IPT further differentiates it from lymphoma. [4]

Urinary tract involvement was first described in 1980 by Roth [5] who reported a case of urinary bladder IPT. It can occur at any age; however, it is rare in children and generally appears in young adults with a median age of 28 years. Painless gross hematuria is usually the presenting clinical manifestation and may result in anemia. Other symptoms include frequency of urination, dysuria and features of urinary tract obstruction. The radiologic features of IPT are variable and non-specific. Polypoidal enhancing intraluminal mass or sub-mucosal mass with or without perivesical fat involvement is usually the common imaging findings. IPT should be considered when an enhancing tumor is surrounded by a clot, particularly in young adults. [6] Cystourethroscopy clinches the diagnosis if there is a polypoidal, nodular or broad based mass, ulceration may also be seen; however, it may just completely miss a sub-mucosal mural IPT. Though IPT usually remains confined to lamina propria, infiltration of muscularis propria and perivesical tissue is not uncommon; adjacent organs may also be involved. Any part of the bladder can be involved by the IPT, though trigone is rarely involved. Management of IPT of bladder has been a contentious issue. If pre-operative diagnosis is established, complete local excision of the bladder mass, either transurethral resection or partial cystectomy as determined by the extent of the lesion, is a conventional acceptable treatment; however long-term follow-up with frequent cystoscopic examination of the patient is advisable. Medical management of the IPT, either using long-term antibiotics and/or anti-inflammatory drugs (steroidal or non-steroidal), is a worthwhile option and is being increasingly reported in the literature. [7],[8] Spontaneous regression of IPT of bladder has also been described in the literature. [9] Possibility of uniform standard guidelines for the management of IPT seems remote in view of rarity of the lesion and its bizarre presentation.

To conclude, IPT poses a diagnostic challenge to clinicians radiologically and endoscopically; however, its accurate pre-operative identification may preclude unwarranted radical resections.


1Brunn H. Two interesting benign tumors of contradictory histopathology. Remarks on the necessity for maintaining the chest tumor registry. J Thorac Surg 1939;9:119-31.
2Umiker WO, Iverson LC. Post inflammatory tumor of the lung: Report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Surg 1954;28:55-62.
3Young RH. Tumor-like lesions of the urinary bladder. Mod Pathol 2009;22 Suppl 2:S37-52.
4Narla LD, Newman B, Spottswood SS, Narla S, Kolli R. Inflammatory pseudotumor. Radiographics 2003;23:719-29.
5Roth JA. Reactive pseudosarcomatous response in urinary bladder. Urology 1980;16:635-7.
6Park SB, Cho KS, Kim JK, Lee JH, Jeong AK, Kwon WJ, et al. Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol 2008;191:1255-62.
7Fletcher SG, Galgano MT, Michalsky MP, Roth JA. Regression of inflammatory pseudotumor of the bladder in a child with medical management. Urology 2007;69:982.e11-2.
8Kunieda F, Inoue K, Terai A. Plasma cell granuloma of the urinary bladder responsive to corticosteroid therapy. Int J Urol 2009;16:428.
9Mochizuki Y, Kanda S, Nomata K, Hayashi T, Yamasaki Y, Kanetake H, et al. Spontaneous regression of inflammatory pseudotumor of the urinary bladder. Urol Int 1999;63:255-7.