Urology Annals

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 7  |  Issue : 2  |  Page : 205--210

A randomized, double-blind, placebo-controlled, crossover trial of DQon-demandDQ tramadol for treatment of premature ejaculation


Adel Kurkar1, Ahmad A Elderwy1, Sherief Abulsorour1, Sara M Awad2, Ahmed S Safwat1, Ahmed Altaher1 
1 Department of Urology, Assiut University Hospitals, Assiut 71515, Egypt
2 Department of Dermatology and Venorology, Assiut University Hospitals, Assiut 71515, Egypt

Correspondence Address:
Dr. Ahmad A Elderwy
Department of Urology, Assiut University Hospitals, Assiut 71515
Egypt

Objectives: The objective of this study is to assess the dose-related effects of tramadol on a group of patients with premature ejaculation (PE). Subjects and Methods: During the period of months between June 2010 and July 2012, 180 PE patients presented to outpatient clinic of our hospital. Patients were randomized in a 1:1:1 fashion to receive different sequences of the three medications: placebo, 50 mg of tramadol and 100 mg of tramadol. Every patient received 10 doses of each medication for 2 months. Intra-vaginal ejaculatory latency time (IELT) was recorded in seconds initially and for each arm. Successful treatment of PE is defined if IELT exceeded 120 s. Side-effects of medications were reported. Results: Of patients enrolled, 125 (69.4%) continued the study. PatientsSQ age range was 20-55 years with PE complaint of 1 to 10 years duration. Mean IELT was 72 at presentation, 82 for placebo, 150 for tramadol 50 mg, and 272 for tramadol 100 mg (P < 0.001 for all comparisons). PE was successfully treated in only 2.4% of patients with placebo, in contrast to 53.6% and 85.6% with 50 and 100 mg tramadol, respectively (P < 0.001 for all comparisons). On multivariate logistic regression analysis, baseline IELT was the only predictor of successful treatment of PE with both tramadol 50 mg (odds ratio [OR]: 1.05, 95% confidence interval [CI]: 1.03-1.07, P < 0.001) and tramadol 100 mg (OR: 1.07, 95% CI: 1.04-1.11, P < 0.001). Postmicturition dribble annoyed 12.8% of those who received 50 mg tramadol and 33.6% of those who received 100 mg tramadol (P < 0.001). Weak scanty ejaculation was the main complaint in 7.2% versus 21.6% of those using 50 and 100 mg tramadol, respectively (P = 0.002). Two patients discontinued tramadol 100 mg due to side-effects. Conclusion: Tramadol hydrochloride exhibits a significant dose-related efficacy and side-effects over placebo for treatment of PE.


How to cite this article:
Kurkar A, Elderwy AA, Abulsorour S, Awad SM, Safwat AS, Altaher A. A randomized, double-blind, placebo-controlled, crossover trial of "on-demand" tramadol for treatment of premature ejaculation.Urol Ann 2015;7:205-210


How to cite this URL:
Kurkar A, Elderwy AA, Abulsorour S, Awad SM, Safwat AS, Altaher A. A randomized, double-blind, placebo-controlled, crossover trial of "on-demand" tramadol for treatment of premature ejaculation. Urol Ann [serial online] 2015 [cited 2020 Oct 21 ];7:205-210
Available from: https://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=2;spage=205;epage=210;aulast=Kurkar;type=0