Year : 2016 | Volume
: 8 | Issue : 2 | Page : 151--156
Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy
Pranav Sharma, Kamran Zargar-Shoshtari, Philippe E Spiess, Wade J Sexton, Michael A Poch
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA
Purpose: We determined the prevalence of prostatic malignancy in patients undergoing radical cystoprostatectomy (RC) for urothelial carcinoma (UC) with a history of radiation therapy (XRT) treatment for prostatic adenocarcinoma (PCa).
Materials and Methods: Fifty-three men who underwent a RC for UC that were previously treated for PCa with XRT were retrospectively identified. Pathology reports were reviewed to assess for residual PCa or prostatic UC at the time of surgery.
Results: Thirteen (25%) patients had residual PCa, 16 (30%) had prostatic UC, and 8 (15%) had both. Sixteen (30%) patients had no evidence of prostatic disease. Patients with PCa had median tumor volume of 2.2 cc (interquartile range: 1.2–2.5 cc) and one-third had high-risk features (Gleason score >8 or pT3-T4 disease). Sixteen of 24 patients (67%) with prostatic UC had a stromal invasion, 5 (21%) had a ductal invasion, and 3 (13%) had carcinoma in situ. Tumors at bladder neck or trigone during transurethral resection were predictive of prostatic UC (odds ratio: 4.32, 95% confidence interval: 1.2–15.5, P = 0.025).
Conclusions: Despite prior XRT for PCa, less than one-third of patients had no prostatic disease at the time of RC. Routine prostatic sampling should be considered in these patients especially if considering the orthotopic diversion.
H. Lee Moffi tt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612
|How to cite this article:|
Sharma P, Zargar-Shoshtari K, Spiess PE, Sexton WJ, Poch MA. Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy.Urol Ann 2016;8:151-156
|How to cite this URL:|
Sharma P, Zargar-Shoshtari K, Spiess PE, Sexton WJ, Poch MA. Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy. Urol Ann [serial online] 2016 [cited 2021 Oct 25 ];8:151-156
Available from: https://www.urologyannals.com/article.asp?issn=0974-7796;year=2016;volume=8;issue=2;spage=151;epage=156;aulast=Sharma;type=0